MAGNESIUM GLYCINATE

Form: Magnesium chelated with glycine (a calming amino acid)
Bioavailability: Very high; one of the best-tolerated forms for the digestive system.

Mechanism of Action

Glycine, an inhibitory neurotransmitter, enhances GABA activity, promoting mental and muscular relaxation. Magnesium glycinate easily crosses the blood–brain barrier, acting on the central nervous system to reduce neuronal hyperactivity and improve sleep onset.

It also supports regulation of the HPA axis, helping reduce excessive cortisol production.

Main Benefits

• Calms the nervous system, helping reduce stress and anxiety.
• Supports muscle relaxation and helps prevent tension or cramps.
• Improves sleep quality and deep restorative phases.
• Supports cardiovascular health and energy metabolism.

Warnings

• Generally well tolerated.
• Not recommended in advanced kidney failure.
• May enhance the calming effects of anxiolytics or muscle relaxants.

MAGNESIUM MALATE

Form: Magnesium bound to malic acid (naturally found in apples)
Bioavailability: High; excellent absorption and digestive tolerance.

Mechanism of Action

Malic acid is a key component of the Krebs cycle, the metabolic pathway by which cells produce ATP. Magnesium malate stimulates mitochondrial energy production, improving physical and mental performance while reducing fatigue.

It acts on muscle and liver tissue, supporting the elimination of metabolites and reducing lactic acid accumulation.

Main Benefits

• Increases cellular energy and daytime endurance.
• Improves post-exercise recovery and reduces fatigue.
• Supports muscle health by reducing tightness and soreness.
• Aids iron metabolism and cellular oxygenation.

Warnings

• Avoid in cases of kidney insufficiency.
• Should not be combined with aluminum-containing medications or antibiotics without medical supervision.
• Often preferred in people with chronic fatigue syndrome or fibromyalgia.

MAGNESIUM CITRATE

Form: Magnesium combined with citric acid
Bioavailability: Very high; one of the most soluble and well-absorbed forms.

Mechanism of Action

Supports activation of energy enzymes and regulation of body pH. Promotes gentle intestinal motility, aids liver detoxification, and contributes to electrolyte balance.

Magnesium citrate also supports nervous system function by balancing neuromuscular excitability, promoting calmness and smoother transition into deep sleep.

Main Benefits

• Supports digestion and healthy bowel regularity.
• Helps reduce muscle tension and spasms.
• Contributes to restorative sleep and emotional stability.
• Supports liver function and acid–base balance.

Warnings

• May have a mild laxative effect, especially at higher doses.
• Not recommended for people with chronic diarrhea or active IBS.

Malate + Glycinate + Citrate
High Absorption | Stress Regulation | Sleep & Cellular Energy Optimization

OVERALL MECHANISM OF ACTION

Magnesium acts as an enzymatic cofactor, activating more than 300 enzymes involved in protein synthesis, muscle contraction, synaptic transmission, and mitochondrial energy production.

It also modulates calcium channels in cell membranes, reducing neuronal excitability and promoting a calming effect on the central nervous system.

Magnesium deficiency is associated with insomnia, anxiety, chronic fatigue, muscle tightness, and elevated cortisol (the primary stress hormone).

WHY COMBINE ALL THREE FORMS?

The combination of Glycinate, Malate, and Citrate allows the formula to act on multiple physiological systems simultaneously:

• Glycinate: Calming, cortisol-regulating, sleep-enhancing.
• Malate: Restores cellular energy and combats daytime fatigue.
• Citrate: Balances electrolytes, improves digestion, and supports liver function.

This synergy enhances modulation of the cortisol–serotonin–GABA axis, essential for balancing the nervous system and promoting overall well-being.

The result is a high-absorption, full-spectrum supplement that improves nighttime rest while supporting daytime energy and focus.

RECOMMENDED FOR

• Individuals with chronic stress, anxiety, or difficulty sleeping.
• Athletes or those with high physical or mental demands.
• People with fatigue, cramps, or frequent muscle tension.
• Anyone looking to improve energy, focus, and daily performance.

NOT RECOMMENDED FOR

• Individuals with moderate or severe kidney disease.
• People taking sedative or hypnotic medications without supervision.
• Individuals with active diarrhea (due to the citrate content).